Axitinib
Cat. No.:YN440021
产品名称: | Axitinib |
CAS No.: | 319460-85-0 |
Chemical Name: | N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-benzamide |
Synonyms: | AG-013736 |
分子量: | 386.47 |
分子式: | C₂₂H₁₈N₄OS |
SMILES: | O=C(C1=C(SC2=CC3=C(C(/C=C/C4=CC=CC=N4)=NN3)C=C2)C=CC=C1)NC |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | Axitinib是多靶点的酪氨酸激酶抑制剂,抑制VEGFR1,VEGFR2,VEGFR3,PDGFRβ的IC50值分别为4,20,4,2 nM。 |
IC50和靶点: | [{name:"VEGFR1:0.1 nM (IC50)"},{name: "VEGFR2:0.2 nM (IC50)"},{name: "VEGFR3:0.1 nM (IC50)"},{name: "PDGFRβ:1.6 nM (IC50)"}] |
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Clinical Trial: | |
Solvent & Solubility: |
Giles, F.J., Bellamy, W.T., Estrov, Z., et al.The anti-angiogenesis agent, AG-013736, has minimal activity in elderly patients with poor prognosis acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS)Leuk. Res.30(7),801-811(2006)
Hu-Lowe, D.D., Zou, H.Y., Grazzini, M.L., et al.Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3Clin. Cancer Res.14(22),7272-7283(2008)