JNJ-10198409
Cat. No.：YN440450
CAS No. ：627518-40-5
规格
价格(RMB)
库存
| 产品名称: | JNJ-10198409 |
| CAS No.: | 627518-40-5 |
| Chemical Name: | N-(3-fluorophenyl)-1,4-dihydro-6,7-dimethoxy-indeno[1,2-c]pyrazol-3-amine |
| Synonyms: | 3-氟-N-(6,7-二甲氧基-2,4-二氢茚并[1,2-C〕吡唑-3-基苯基胺,JNJ-10198409 |
| 分子量: | 325.34 |
| 分子式: | C₁₈H₁₆FN₃O₂ |
| SMILES: | COC1=CC2=C(C=C1OC)CC3=C2NN=C3NC4=CC=CC(F)=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JNJ-10198409 是一种相对选择性的，具有口服活性的，ATP 竞争性的血小板衍生生长因子受体酪氨酸激酶(PDGF-RTK)抑制剂 (IC50=2 nM)。它是一种双重机制的抗血管生成和肿瘤细胞的抗增殖剂。JNJ-10198409 对PDGFR-β激酶 (IC50=4.2 nM) 和PDGFR-α激酶 (IC50=45 nM) 有较好的抑制作用。 |
| IC50和靶点: | [{name:"PDGFRβ:4.2 nM (IC50)"},{name: "PDGFRα:45 nM (IC50)"}] |
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Battegay, E.J., Rupp, J., Iruela-Arispe, L., et al.PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF β-receptorsJ. Cell Biol.125(4),917-928(1994)
Ho, C.Y., Ludovici, D.W., Maharoof, U.S.M., et al.(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: Platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cellsJ. Med. Chem.48(26),8163-8173(2005)
