Rigosertib sodium
Cat. No.：YN420105
CAS No. ：592542-60-4
规格
价格(RMB)
库存
| 产品名称: | Rigosertib sodium |
| CAS No.: | 592542-60-4 |
| Chemical Name: | |
| Synonyms: | ON-01910 sodium |
| 分子量: | 473.47 |
| 分子式: | C₂₁H₂₄NNaO₈S |
| SMILES: | COC1=CC=C(C=C1NCC(O[Na])=O)CS(/C=C/C2=C(C=C(C=C2OC)OC)OC)(=O)=O.[(E)] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rigosertib sodium (ON-01910 sodium) 是一种多激酶抑制剂和选择性抗癌剂，通过抑制PI3K/Akt途径诱导细胞凋亡，促进组蛋白 H2AX 的磷酸化并诱导细胞周期中的 G2/M 期停滞。Rigosertib sodium 是一种选择性的非 ATP 竞争性PLK1抑制剂，IC50值为 9 nM。 |
| IC50和靶点: | [{name:"PLK1:9 nM (IC50)"},{name: "PLK2:260 nM (IC50)"},{name: "PDGFR:18 nM (IC50)"},{name: "Src:155 nM (IC50)"},{name: "BCR-ABL:32 nM (IC50)"},{name: "Cdk1:260 nM (IC50)"},{name: "Flt1:42 nM (IC50)"},{name: "Fyn:182 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
