Vps34-IN-1
Cat. No.：YN420138
CAS No. ：1383716-33-3
规格
价格(RMB)
库存
| 产品名称: | Vps34-IN-1 |
| CAS No.: | 1383716-33-3 |
| Chemical Name: | 1-[[2-[(2-chloro-4-pyridinyl)amino]-4'-(cyclopropylmethyl)[4,5'-bipyrimidin]-2'-yl]amino]-2-methyl-2-propanol |
| Synonyms: | Vps34-IN-1 |
| 分子量: | 425.91 |
| 分子式: | C₂₁H₂₄ClN₇O |
| SMILES: | CC(C)(O)CNC1=NC=C(C2=CC=NC(NC3=CC=NC(Cl)=C3)=N2)C(CC4CC4)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Vps34-IN-1是Vps34的抑制剂，来自从专利WO2012085815A1，化合物实例16a，IC50为4nM。Vps34-IN-1 调节自噬 (autophagy)。 |
| IC50和靶点: | [{name:"Vps34:4 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Bago, R., Malik, N., Munson, M.J., et al.Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinaseBiochem.J.463(3),413-427(2014)
