YM-201636
Cat. No.：YN420154
CAS No. ：371942-69-7
规格
价格(RMB)
库存
| 产品名称: | YM-201636 |
| CAS No.: | 371942-69-7 |
| Chemical Name: | 6-amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide |
| Synonyms: | YM 201636; YM-201636 |
| 分子量: | 467.48 |
| 分子式: | C₂₅H₂₁N₇O₃ |
| SMILES: | O=C(NC1=CC=CC(C2=NC(N3CCOCC3)=C4OC5=NC=CC=C5C4=N2)=C1)C6=CC=C(N=C6)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | YM-201636 是高效选择性的PIKfyve抑制剂，IC50值为 33 nM。YM-201636 也抑制 p110α，IC50为 3.3 μM。YM-201636 可抑制逆转录病毒复制。 |
| IC50和靶点: | [{name:"PIKfyve:33 nM (IC50)"},{name: "p110α:3.3 μM (IC50)'}, 'Autophagy'] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Jefferies, H.B.J., Cooke, F.T., Jat, P., et al.A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral buddingEMBO reports9(2),164-170(2008)
Ikonomov, O.C., Sbrissa, D., and Shisheva, A.YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytesBiochem. Biophys. Res. Commun.382(3),566-570(2009)
