H-89 dihydrochloride
Cat. No.：YN440356
CAS No. ：130964-39-5
规格
价格(RMB)
库存
| 产品名称: | H-89 dihydrochloride |
| CAS No.: | 130964-39-5 |
| Chemical Name: | N-[2-[[3-(4-bromophenyl)-2-propen-1-yl]amino]ethyl]5-isoquinolinesulfonamide, dihydrochloride |
| Synonyms: | H 89 2HCl,5-Isoquinolinesulfonamide,Protein kinase inhibitor H-89 dihydrochloride |
| 分子量: | 519.28 |
| 分子式: | C₂₀H₂₂BrCl₂N₃O₂S |
| SMILES: | O=S(C1=CC=CC2=C1C=CN=C2)(NCCNC/C=C/C3=CC=C(Br)C=C3)=O.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | H-89 dihydrochloride 是一种有效、选择性的 cAMP 依赖性蛋白激酶A (PKA) 抑制剂，IC50值为 48 nM。也可轻微抑制 PKG，PKC，酪蛋白激酶活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Davies, S.P., Reddy, H., Caivano, M., et al.Specificity and mechanism of action of some commonly used protein kinase inhibitorsBiochem. J.351(1),95-105(2000)
Engh, R.A., Girod, A., Kinzel, V., et al.Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89 structural implications for selectivityJ. Biol. Chem.271(42),26157-26164(1996)
