RIPA-56
Cat. No.：YN270024
CAS No. ：1956370-21-0
| 产品名称: | RIPA-56 |
| CAS No.: | 1956370-21-0 |
| Chemical Name: | N-hydroxy-2,2-dimethyl-N-(phenylmethyl)-butanamide |
| Synonyms: | RIPA56; RIPA 56 |
| 分子量: | 221.30 |
| 分子式: | C₁₃H₁₉NO₂ |
| SMILES: | CCC(C)(C)C(N(CC1=CC=CC=C1)O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RIPA-56 是一种高效选择和代谢稳定的受体相互作用蛋白 1 (RIP1) 抑制剂，IC50为 13 nM。RIPA-56 可用于研究全身炎症反应综合征。 |
| IC50和靶点: | |
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Ren, Y., Su, Y., Sun, L., et al.Discovery of a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) for the treatment of systemic inflammatory response syndromeJ. Med. Chem.60(3),972-986(2017)
Zhang, S., Su, Y., Ying, Z., et al.RIP1 kinase inhibitor halts the progression of an immune-induced demyelination disease at the stage of monocyte elevationProc. Natl. Acad. Sci. USA116(12),5675-5680(2019)
Majdi, A., Aoudjehane, L., Ratziu, V., et al.Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver diseaseJ. Hepatol.72(4),627-635(2020)
