Ziprasidone hydrochloride monohydrate
Cat. No.：YN321131
| 产品名称: | Ziprasidone hydrochloride monohydrate |
| CAS No.: | 138982-67-9 |
| Chemical Name: | 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one, monohydrochloride, monohydrate |
| Synonyms: | 盐酸齐拉西酮水合物; CP 88059 hydrochloride monohydrate |
| 分子量: | 467.41 |
| 分子式: | C₂₁H₂₄Cl₂N₄O₂S |
| SMILES: | O=C1CC2=CC(CCN3CCN(C4=NSC5=C4C=CC=C5)CC3)=C(Cl)C=C2N1.[H]Cl.O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ziprasidone (CP 88059) hydrochloride monohydrate是一种抗精神病药物，是具有口服活性的5-HT (serotonin)和多巴胺受体(dopamine receptor) 拮抗剂的联合用药。Ziprasidone hydrochloride monohydrate对大鼠 (Ki: 3.4 nM) 和人 (2.5 nM) 5-HT1A，5-HT2A (0.42 nM) 和 dopamine D2 (4.8 nM) 受体有很高的亲和力。Ziprasidone hyd |
| IC50和靶点: | [{name:"Rat 5-HT2A:0.42 nM (Ki)"},{name: "Rat 5-HT1A Receptor:3.4 nM (Ki)"},{name: "Rat D2 Receptor:4.8 nM (Ki)"}] |
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Seeman, P.Atypical antipsychotics: Mechanism of actionCan. J. Psychiatry47(1),27-38(2002)
Schmidt, A.W., Lebel, L.A., Howard, H.R., Jr., et al.Ziprasidone: A novel antipsychotic agent with a unique human receptor binding profileEur. J. Pharmacol.425(3),197-201(2001)
Audinot, V., Newman-Tancredi, A., Cussac, D., et al.Inverse agonist properties of antipsychotic agents at cloned, human (h) serotonin (5-HT)1B and h5-HT1D receptorsNeuropsychopharmacology25(3),410-422(2001)
Seeger, T.F., Seymour, P.A., Schmidt, A.W., et al.Ziprasidone (CP-88,059): A new antipsychotic with combined dopamine and serotonin receptor antagonist activityJ. Pharmacol. Exp. Ther.275(1),101-113(1995)
