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Sirtinol

Cat. No.：410536-97-9

  • CAS No. ：410536-97-9

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    • 产品名称: Sirtinol
      CAS No.: 410536-97-9
      Chemical Name:
      Synonyms:2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺
      分子量:394.47
      分子式:C₂₆H₂₂N₂O₂
      SMILES:O=C(NC(C1=CC=CC=C1)C)C2=CC=CC=C2/N=C/C3=C4C=CC=CC4=CC=C3O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 0.98
    • Grozinger, C.M., Chao, E.D., Blackwell, H.E., et al.Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screeningJ. Biol. Chem.276(42),38837-38843(2001)', 'Ota, H., Tokunaga, E., Chang, K., et al.Sirt1 inhibitor, sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cellsOncogene25(2),176-185(2006)', 'Cea, M., Soncini, D., Fruscione, F., et al.Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cellsPLoS One6(7),1-12(2011)', 'Orecchia, A., Scarponi, C., Di Felice, F., et al.Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cellsPLoS One6(9),1-12(2011)', 'Zhao, Y., Dai, X., Blackwell, H.E., et al.SIR1, an upstream component in auxin signaling identified by chemical geneticsScience301(5636),1107-1110(2003)', 'Dai, X., Hayashi, K.i., Nozaki, H., et al.Genetic and chemical analyses of the action mechanisms of sirtinol in ArabidopsisProc. Natl. Acad. Sci. USA102(8),3129-3134(2005)
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