AK-1
Cat. No.：YN310042
CAS No. ：330461-64-8
| 产品名称: | AK-1 |
| CAS No.: | 330461-64-8 |
| Chemical Name: | 3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-N-(3-nitrophenyl)-benzamide |
| Synonyms: | AK-1，AK1,AK 1 |
| 分子量: | 403.45 |
| 分子式: | C₁₉H₂₁N₃O₅S |
| SMILES: | O=C(NC1=CC=CC([N+]([O-])=O)=C1)C2=CC=CC(S(=O)(N3CCCCCC3)=O)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AK-1是一种有效的，特异性的和细胞可渗透的SIRT2抑制剂，其IC50值为 12.5 μM。 |
| IC50和靶点: | [{name:"SIRT2:12.5 μM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Taylor, D.M., Balabadra, U., Xiang, Z., et al.A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylaseACS Chem Biol.6(6),540-546(2011)
Outeiro, T.F., Kontopoulos, E., Altmann, S.M., et al.Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's diseaseScience317(5837),516-519(2007)
Lee, S.D., Kim, W., Jeong, J.-W., et al.AK-1, a SIRT2 inhibitor, destabilizes HIF-1α and diminishes its transcriptional activity during hypoxiaCancer Lett.373(1),138-145(2016)
Luthi-Carter, R., Taylor, D.M., Pallos, J., et al.SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesisProc. Natl. Acad. Sci. USA107(17),7927-7932(2010)
