Sirtuin modulator 1
Cat. No.：YN310329
CAS No. ：2070015-26-6
| 产品名称: | Sirtuin modulator 1 |
| CAS No.: | 2070015-26-6 |
| Chemical Name: | 5-(3-methoxypropyl)-2-phenyl-N-[2-[6-(1-pyrrolidinylmethyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]-4-thiazolecarboxamide, monohydrochloride |
| Synonyms: | SRT3025 Hydrochloride |
| 分子量: | 606.20 |
| 分子式: | C₃₁H₃₂ClN₅O₂S₂ |
| SMILES: | O=C(C1=C(CCCOC)SC(C2=CC=CC=C2)=N1)NC3=CC=CC=C3C4=NC5=C(N=CC(CN6CCCC6)=C5)S4.Cl[H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sirtuin modulator 1 是SIRTl(SIRT3 的同系物) 的调节剂，EC1.5值 < 1 μM，摘自专利 WO 2010071853 A1，化合物 4。 |
| IC50和靶点: | [{name:"SIRT1:1 μM (EC1.5)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Gurt, I., Artsi, H., Cohen-Kfir, E., et al.The Sirt1 activators SRT2183 and SRT3025 Inhibit RANKL-induced osteoclastogenesis in bone marrow-derived macrophages and down-regulate Sirt3 in Sirt1 null cellsPLoS One10(7),e0134391(2015)
Chini, C.C.S., Espindola-Netto, J.M., Mondal, G., et al.SIRT1-activating compounds (STAC) negatively regulate pancreatic cancer cell growth and viability through a SIRT1 lysosomal-dependent pathwayClin. Cancer Res.22(10),2496-2507(2015)
Miranda, M.X., van Tits, L.J., Lohmann, C., et al.The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expressionEur. Heart J.36(1),51-59(2015)
