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Rubitecan

Cat. No.：91421-42-0

  • CAS No. ：91421-42-0

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    • 产品名称: Rubitecan
      CAS No.: 91421-42-0
      Chemical Name:
      Synonyms:RFS 2000; 9-Nitrocamptothecin
      分子量:393.35
      分子式:C₂₀H₁₅N₃O₆
      SMILES:O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C([N+]([O-])=O)C=CC=C5N=C4C3=C2)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 0.98
    • Rubin, E., Pantazis, P., Bharti, A., et al.Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-nitro-camptothecinJ. Biol. Chem.269(4),2433-2439(1994)', 'Hinz, H.R., Harris, N.J., Natelson, E.A., et al.Pharmacokinetics of the in vivo and in vitro conversion of 9-nitro-20(S)-camptothecin to 9-amino-20(S)-camptothecin in humans, dogs, and miceCancer Res.54(12),3096-3100(1994)', 'Bernacki, R.J., Pera, P., Gambacorta, P., et al.In vitro antitumor activity of 9-nitro-camptothecin as a single agent and in combination with other antitumor drugsAnn. N. Y. Acad. Sci.922,293-297(2000)', 'Pantazis, P., Mendoza, J.T., Early, J.A., et al.9-Nitro-camptothecin delays growth of U-937 leukemia tumors in nude mice and is cytotoxic or cytostatic for human myelomonocytic leukemia lines in vitroEur. J. Haematol.50(2),81-89(1993)
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