Ki8751
Cat. No.：YN440184
CAS No. ：228559-41-9
规格
价格(RMB)
库存
| 产品名称: | Ki8751 |
| CAS No.: | 228559-41-9 |
| Chemical Name: | N-(2,4-difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]-urea |
| Synonyms: | Ki8751;1-(2,4-difluorophenyl)-3-(4-(6,7-diMethoxyquinolin-4-yloxy)-2-fluorophenyl)urea;1-(2,4-difluorophenyl)-3-[4-(6,7-dimethoxyquinolin-4-yl)oxy-2-fluorophenyl]urea;Ki-8751;Ki-8751,Ki8751;N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2- |
| 分子量: | 469.41 |
| 分子式: | C₂₄H₁₈F₃N₃O₄ |
| SMILES: | COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C(F)=C3)NC(NC4=CC=C(C=C4F)F)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ki8751是有效地VEGFR2抑制剂，IC50值为0.9 nM。 |
| IC50和靶点: | [{name:"VEGFR2:0.9 nM (IC50)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Kubo, K., Shimizu, T., Ohyama, S., et al.Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: Synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureasJ. Med. Chem.48(5),1359-1366(2005)
Hasan, M.R., Ho, S.H.Y., Owen, D.A., et al.Inhibition of VEGF induces cellular senescence in colorectal cancer cellsInt. J. Cancer129(9),2115-2123(2011)
