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SU1498

Cat. No.:YN440389

  • CAS No. :168835-82-3

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    • 产品名称: SU1498
      CAS No.: 168835-82-3
      Chemical Name: (2E)-2-cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-2-propenamide
      Synonyms:AG 1498; Tyrphostin SU 1498
      分子量:390.52
      分子式:C₂₅H₃₀N₂O₂
      SMILES:O=C(NCCCC1=CC=CC=C1)/C(C#N)=C/C2=CC(C(C)C)=C(O)C(C(C)C)=C2
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: SU1498 (AG 1498) 是选择性的VEGFR2抑制剂;抑制Flk-1的IC50值为 700 nM。
      IC50和靶点: [{name:"Flk-1:700 nM (IC50)"}]
      In Vitro:
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      Solvent & Solubility:
    • Strawn, L.M., McMahon, G., App, H., et al.Flk-1 as a target for tumor growth inhibitionCancer Res.56(15),3540-3545(1996)

      Fedorov, O., Marsden, B., Pogacic, V., et al.A systematic interaction map of validated kinase inhibitors with Ser/Thr kinasesProc. Natl. Acad. Sci. USA104(51),20523-20528(2007)

      Arbiser, J.L., Larsson, H., Claesson-Welsh, L., et al.Overexpression of VEGF 121 in immortalized endothelial cells causes conversion to slowly growing angiosarcoma and high level expression of the VEGF receptors VEGFR-1 and VEGFR-2 in vivoAm. J. Pathol.156(4),1469-1476(2000)

      Francescone, R., Scully, S., Bentley, B., et al.Glioblastoma-derived tumor cells induce vasculogenic mimicry through Flk-1 protein activationJ. Biol. Chem.287(29),24821-24831(2012)

      Harms, K.M., Li, L., and Cunningam, L.A.Murine neural stem/progenitor cells protect neurons against ischemia by HIF-1α-regulated VEGF signalingPLoS One5(3),1-12(2010)

      Pan, Z., Fukuoka, S., Karagianni, N., et al.Vascular endothelial growth factor promotes anatomical and functional recovery of injured peripheral nerves in the avascular corneaFEBS J.27(7),2756-2767(2013)

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