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ZM 306416

Cat. No.:YN440290

  • CAS No. :690206-97-4

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    • 产品名称: ZM 306416
      CAS No.: 690206-97-4
      Chemical Name: N-(4-chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine
      Synonyms:CB 676475
      分子量:333.74
      分子式:C₁₆H₁₃ClFN₃O₂
      SMILES:COC1=CC2=NC=NC(NC3=C(F)C=C(Cl)C=C3)=C2C=C1OC
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: ZM-306416 (CB 676475) 是VEGFR的有效抑制剂,对KDR 和 Flt的IC50值分别为0.1 和 2 μM。ZM-306416 也是EGFR的抑制剂,IC50值小于10 nM。
      IC50和靶点: [{name:"KDR:100 nM (IC50)"},{name: "Flt-1:2 μM (IC50)"}]
      In Vitro:
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      Solvent & Solubility:
    • Hennequin, L.F., Thomas, A.P., Johnstone, C., et al.Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitorsJ. Med. Chem.42(26),5369-5389(1999)

      Antczak, C., Mahida, J.P., Bhinder, B., et al.A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: Implications in drug discoveryJ. Biomol. Screen.17(7),885-899(2012)

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