Exemestane
Cat. No.：YN481282
CAS No. ：107868-30-4
规格
价格(RMB)
库存
| 产品名称: | Exemestane |
| CAS No.: | 107868-30-4 |
| Chemical Name: | 6-methylene-androsta-1,4-diene-3,17-dione |
| Synonyms: | 依西美坦; FCE 24304; EXE |
| 分子量: | 296.40 |
| 分子式: | C₂₀H₂₄O₂ |
| SMILES: | C[C@]1([C@](CC2)([H])[C@]3([H])CC(C4=CC(C=C[C@]4(C)[C@@]3([H])CC1)=O)=C)C2=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Exemestane (FCE 24304) 是一种选择性，不可逆和具有口服活性的甾体芳香酶 (aromatase) 抑制剂，对人胎盘和大鼠卵巢芳香酶的IC50分别为 30 nM 和 40 nM。Exemestane 可用于激素依赖性乳腺癌研究。 |
| IC50和靶点: | |
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Giudici, D., Ornati, G., Briatico, G., et al.6-Methylenandrosta-1,4-diene-3,17-dione (FCE 24304): A new irreversible aromatase inhibitorJ. Steroid Biochem.30(1-6),391-394(1988)
Zaccheo, T., Giudici, D., Lombardi, P., et al.A new irreversible aromatase inhibitor, 6-methylenandrosta-1,4-diene-3,17-dione (FCE 24304): Antitumor activity and endocrine effects in rats with DMBA-induced mammary tumorsCancer Chemother. Pharmacol.23(1),47-50(1989)
