Fadrozole hydrochloride
Cat. No.：YN481382
CAS No. ：102676-31-3
规格
价格(RMB)
库存
| 产品名称: | Fadrozole hydrochloride |
| CAS No.: | 102676-31-3 |
| Chemical Name: | 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-benzonitrile, monohydrochloride |
| Synonyms: | CGS 16949A |
| 分子量: | 259.73 |
| 分子式: | C₁₄H₁₄ClN₃ |
| SMILES: | N#CC1=CC=C(C2CCCC3=CN=CN23)C=C1.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fadrozole hydrochloride 是一种有效，选择性和非甾体类的aromatase抑制剂，其IC50值为 6.4 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Bhatnagar, A.S., Häusler, A., Schieweck, K., et al.Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitorJ. Steroid Biochem. Mol. Biol.37(6),1021-1027(1990)
Steele, R.E., Mellor, L.B., Sawyer, W.K., et al.In vitro and in vivo studies demonstrating potent and selective estrogen inhibition with the nonsteroidal aromatase inhibitor CGS 16949ASteroids50(1-3),147-161(1987)
Mast, N., Lin, J.B., and Pikuleva, I.A.Marketed drugs can inhibit cytochrome P450 27A1, a potential new target for breast cancer adjuvant therapyMol. Pharmacol.88(3),428-436(2015)
Tekmal, R.R., and Durgam, V.R.A novel in vitro and in vivo breast cancer model for testing inhibitors of estrogen biosynthesis and its action using mammary tumor cells with an activated int-5/aromatase geneCancer Lett.118(1),21-28(1997)
