Letrozole
Cat. No.：YN481384
CAS No. ：112809-51-5
规格
价格(RMB)
库存
| 产品名称: | Letrozole |
| CAS No.: | 112809-51-5 |
| Chemical Name: | 4,4'-(1H-1,2,4-triazol-1-ylmethylene)bis-benzonitrile |
| Synonyms: | 来曲唑; CGS 20267 |
| 分子量: | 285.30 |
| 分子式: | C₁₇H₁₁N₅ |
| SMILES: | N#CC1=CC=C(C(N2C=NC=N2)C3=CC=C(C#N)C=C3)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Letrozole (CGS 20267) 是一种有效的，选择性的，可逆的和具有口服活性的非甾体类芳香化酶 (aromatase) 抑制剂，IC50值为 11.5 nM。Letrozole 选择性抑制雌激素的生物合成，可用于乳腺癌的研究。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Mayhoub, A.S., Marler, L., Kondratyuk, T.P., et al.Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrolBioorg. Med. Chem.20(7),2427-2434(2012)
Mitropoulou, T.N., Tzanakakis, G.N., Kletsas, D., et al.Letrozole as a potent inhibitor of cell proliferation and expression of metalloproteinases (MMP-2 and MMP-9) by human epithelial breast cancer cellsInt. J. Cancer104(2),155-160(2003)
Long, B.J., Jelovac, D., Handratta, V., et al.Therapeutic strategies using the aromatase inhibitor letrozole and tamoxifen in a breast cancer modelJ. Natl. Cancer Inst.96(6),456-465(2004)
Cohen, M.H., Johnson, J.R., Li, N., et al.Approval summary: Letrozole in the treatment of postmenopausal women with advanced breast cancerClin Cancer Res.8(3),665-669(2002)
