Ezetimibe
Cat. No.：YN410072
CAS No. ：163222-33-1
规格
价格(RMB)
库存
| 产品名称: | Ezetimibe |
| CAS No.: | 163222-33-1 |
| Chemical Name: | (3R,4S)-1,4-fluorophenyl-3-[(3S-3-4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone |
| Synonyms: | 依泽替米贝; SCH 58235 |
| 分子量: | 409.43 |
| 分子式: | C₂₄H₂₁F₂NO₃ |
| SMILES: | O=C1N(C2=CC=C(F)C=C2)[C@H](C3=CC=C(O)C=C3)[C@H]1CC[C@@H](C4=CC=C(F)C=C4)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ezetimibe (SCH 58235) 是有效的胆固醇吸收 (cholesterol-absorption) 抑制剂。Ezetimibe 是一种NPC1L1抑制剂，是有效的Nrf2激活剂。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Garcia-Calvo, M., Lisnock, J., Bull, H.G., et al.The target of ezetimibe is Niemann-Pick C1-like 1 (NPC1L1)Proc. Natl. Acad. Sci. USA102(23),8132-8137(2005)
Rosenblum, S.B., Huynh, T., Afonso, A., et al.Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4 -hydroxyphenyl)-2-azetidinone (SCH 58235): A designed, potent, orally active inhibitor of cholesterol absorptionJ. Med. Chem.41(6),973-980(1998)
Shaw, S.M., Najam, O., Khan, U., et al.Ezetimibe and atorvastatin both immunoregulate CD4+ T cells from cardiac transplant recipients in vitroTranspl. Immunol.21(3),179-182(2009)
