KU-55933
Cat. No.：YN420101
CAS No. ：587871-26-9
规格
价格(RMB)
库存
| 产品名称: | KU-55933 |
| CAS No.: | 587871-26-9 |
| Chemical Name: | 2-(4-morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one |
| Synonyms: | ATM Kinase Inhibitor |
| 分子量: | 395.49 |
| 分子式: | C₂₁H₁₇NO₃S₂ |
| SMILES: | O=C1C=C(OC(C2=C3SC4=C(SC3=CC=C2)C=CC=C4)=C1)N5CCOCC5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KU-55933 是有效的ATM抑制剂，IC50和Ki值分别为 12.9 和 2.2 nM；对 ATM 的选择性比对 DNA-PK，PI3K/PI4K，ATR 和 mTOR 高。 |
| IC50和靶点: | [{name:"ATM:12.9 nM (IC50)"},{name: "DNA-PK:2500 nM (IC50)"},{name: "mTOR:9300 nM (IC50)"},{name: "PI3K:16600 nM (IC50)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Hickson, I., Zhao, Y., Richardson, C.J., et al.Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATMCancer Res.64(24),9152-9159(2004)
Crescenzi, E., Palumbo, G., de Boer, J., et al.Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: Implications for chemotherapyClin. Cancer Res.14(6),1877-1887(2008)
Lau, A., Swinbank, K.M., Ahmed, P.S., et al.Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinaseNat. Cell Biol.7(5),493-500(2005)
