NU6027
Cat. No.：YN420183
CAS No. ：220036-08-8
规格
价格(RMB)
库存
| 产品名称: | NU6027 |
| CAS No.: | 220036-08-8 |
| Chemical Name: | 6-(cyclohexylmethoxy)-5-nitroso-2,4-pyrimidinediamine |
| Synonyms: | NU6027，NU-6027，NU 6027 |
| 分子量: | 251.28 |
| 分子式: | C₁₁H₁₇N₅O₂ |
| SMILES: | NC1=NC(OCC2CCCCC2)=C(N=O)C(N)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NU6027 是一种有效且的、ATP竞争性的CDK1和CDK2的抑制剂，Ki值分别为 2.5 µM 和 1.3 µM。NU6027 也是ATR的有效抑制剂，以 ATR 依赖性方式增强羟基脲和顺铂的细胞毒性。 |
| IC50和靶点: | [{name:"CDK1:2.5 μM (Ki)"},{name: "CDK2:1.3 μM (Ki)'}, 'ATR'] |
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| Solvent & Solubility: |
Sayle, K.L., Bentley, J., Boyle, F.T., et al.Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2Bioorg. Med. Chem. Lett.13(18),3079-3082(2003)
Peasland, A., Wang, L.Z., Rowling, E., et al.Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell linesBr. J. Cancer105(3),372-381(2011)
