KU-60019
Cat. No.：YN420108
CAS No. ：925701-46-8
规格
价格(RMB)
库存
| 产品名称: | KU-60019 |
| CAS No.: | 925701-46-8 |
| Chemical Name: | rel-2R,6S-dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide |
| Synonyms: | KU 60019;KU-60019;ku60019;IAN358A69K;2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-N-[5-(6-morpholin-4-yl-4-oxopyran-2-yl)-9H-thioxanthen-2-yl]acetamide;C30H33N3O5S;2-[(2R,6S)-2,6-Dimethylmorpholin-4-yl]-N-{5-[6-(morpholin-4-yl)-4-oxo-4H-pyran-2-yl]-9H-thioxanth |
| 分子量: | 547.67 |
| 分子式: | C₃₀H₃₃N₃O₅S |
| SMILES: | C[C@@H]1O[C@@H](CN(CC(NC2=CC3=C(C=C2)SC4=C(C3)C=CC=C4C5=CC(C=C(O5)N6CCOCC6)=O)=O)C1)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KU-60019 是一种ATM激酶特异性的抑制剂，IC50为 6.3 nM。 |
| IC50和靶点: | [{name:"ATM:6.3 nM (IC50)"},{name: "DNA-PKcs:1.7 μM (IC50)"}] |
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| Solvent & Solubility: |
Golding, S.E., Rosenberg, E., Valerie, N., et al.Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasionMol. Cancer Ther.8(10),2894-2902(2009)
Golding, S.E., Rosenberg, E., Adams, B.R., et al.Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth controlCell Cycle11(6),1167-1173(2012)
Biddlestone-Thorpe, L., Sajjad, M., Rosenberg, E., et al.ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiationClin. Cancer Res.19(12),3189-3200(2013)
McCabe, N., Hanna, C.D., Walker, S.M., et al.Mechanistic rationale to target PTEN-deficient tumour cells with inhibitors of the DNA damage response kinase ATMCancer Res.75(11),2159-2165(2015)
