AZD4635
Cat. No.：YN1440004
CAS No. ：1321514-06-0
| 产品名称: | AZD4635 |
| CAS No.: | 1321514-06-0 |
| Chemical Name: | 6-(2-chloro-6-methyl-4-pyridinyl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine |
| Synonyms: | HTL1071 |
| 分子量: | 315.73 |
| 分子式: | C₁₅H₁₁ClFN₅ |
| SMILES: | NC1=NC(C2=CC=C(F)C=C2)=C(C3=CC(Cl)=NC(C)=C3)N=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZD4635 (HTL1071) 是一种有效的选择性的，具有口服活性的腺苷 A2A 受体 (A2AR) 拮抗剂。AZD4635 结合人A2AR的Ki为 1.7 nM，对A2AR的选择性是其他腺苷受体的 30 倍以上。 |
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Borodovsky, A., Wang, Y., Ye, M., et al.Abstract 5580: Preclinical pharmacodynamics and antitumor activity of AZD4635, a novel adenosine 2A receptor inhibitor that reverses adenosine mediated T cell suppressionCancer Res.77(13 Supp.),5580(2017)
