CGS 21680 Hydrochloride
Cat. No.：YN1730055
CAS No. ：124431-80-7
| 产品名称: | CGS 21680 Hydrochloride |
| CAS No.: | 124431-80-7 |
| Chemical Name: | 4-[2-[[6-amino-9-(N-ethyl-β-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]-benzenepropanoic acid, monohydrochloride |
| Synonyms: | CGS 21680 HCl |
| 分子量: | 535.98 |
| 分子式: | C₂₃H₃₀ClN₇O₆ |
| SMILES: | O=C(O)CCC1=CC=C(CCNC2=NC3=C(N=CN3[C@H]4[C@H](O)[C@H](O)[C@@H](C(NCC)=O)O4)C(N)=N2)C=C1.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CGS 21680 Hydrochloride 是选择性的adenosine A2A receptor激动剂，Ki值为为 27 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ji, X.d., Gallo-Rodriguez, C., and Jacobson, K.A.A selective agonist affinity label for A3 adenosine receptorsBiochem. Biophys. Res. Commun.203(1),570-576(1994)
Kim, H.O., Ji, X.d., Siddiqi, S.M., et al.2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptorsJ. Med. Chem.37(21),3614-3621(1994)
Klotz, K.-N., Hessling, J., Hegler, J., et al.Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cellsNaunyn-Schmiedeberg's Arch. Pharmacol.357(1),1-9(1998)
Linden, J., Thai, T., Figler, H., et al.Characterization of human A2B adenosine receptors: Radioligand binding, western blotting, and coupling to Gq in human embryonic kidney 293 cells and HMC-1 mast cellsMol. Pharmacol.56(4),705-713(1999)
Varani, K., Merighi, S., Gessi, S., et al.[3H]MRE 3008F20: A novel antagonist radioligand for the pharmacological and biochemical characterization of human A3 adenosine receptorsMol. Pharmacol.57(5),968-975(2000)
Cheng, M.K., Doumad, A.B., Jiang, H., et al.Epoxyeicosatrienoic acids mediate adenosine-induced vasodilation in rat prelomerular microvessels (PGMV) via A2A receptorsBr. J. Pharmacol.141(3),441-448(2004)
Ledent, C., Vaugeois, J.M., Schiffmann, S.N., et al.Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2A receptorNature388(6643),674-678(1997)
Gnad, T., Scheibler, S., von Kügelgen, I., et al.Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptorsNature516(7531),395-399(2014)
