Derenofylline
Cat. No.：YN1570007
CAS No. ：251945-92-3
| 产品名称: | Derenofylline |
| CAS No.: | 251945-92-3 |
| Chemical Name: | trans-4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-cyclohexanol |
| Synonyms: | SLV 320 |
| 分子量: | 308.38 |
| 分子式: | C₁₈H₂₀N₄O |
| SMILES: | O[C@H]1CC[C@H](NC2=C3C(NC=C3)=NC(C4=CC=CC=C4)=N2)CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Derenofylline (SLV 320) 是一个有效的、选择性的、具有口服活性的腺苷A1受体的拮抗剂，其对腺苷A1、A3和A2A受体的Ki值分别为 1 nM、200 nM 和 398 nM。Derenofylline可抑制心肌纤维化，降低蛋白尿，且不影响大鼠血压。 |
| IC50和靶点: | [{name:"A1R:1 nM (Ki)"},{name: "Adenosine A3 receptor:200 nM (Ki)"},{name: "A2AR:398 nM (Ki)"}] |
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Kalk, P., Eggert, B., Relle, K., et al.The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressureBr. J. Pharmacol.151(7),1025-1032(2007)
Micewicz, E.D., Khachatoorian, R., French, S.W., et al.Identification of novel small-molecule inhibitors of Zika virus infectionBioor. Med. Chem. Lett.28(3),452-458(2018)
