BAY-545
Cat. No.：YN1710010
CAS No. ：1699717-32-2
| 产品名称: | BAY-545 |
| CAS No.: | 1699717-32-2 |
| Chemical Name: | 3-ethyl-6-[(4-hydroxy-1-piperidinyl)carbonyl]-5-methyl-1-(3,3,3-trifluoropropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione |
| Synonyms: | 3-Ethyl-6-(4-hydroxypiperidine-1-carbonyl)-5-methyl-1-(3,3,3-trifluoropropyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione;ZB1532;CID 118016229;BAY-545 |
| 分子量: | 433.45 |
| 分子式: | C₁₈H₂₂F₃N₃O₄S |
| SMILES: | CCN1C(N(CCC(F)(F)F)C2=C(C(C)=C(C(N3CCC(O)CC3)=O)S2)C1=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BAY-545 是一种有效、选择性的 A2B腺苷受体 (A2Badenosine receptor) 拮抗剂，IC50值为 59 nM。在细胞中，BAY-545 对人、小鼠、大鼠 A2Badenosine 受体的IC50值分别为 66，400，280 nM，对人 A2Badenosine 受体的Ki值为 97 nM；对其选择性远高于 A1，A2A和 A3受体。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Harter, M., Kalthof, B., Delbeck, M., et al.Novel non-xanthine antagonist of the A2B adenosine receptor: From HTS hit to lead structureEur. J. Med. Chem.163,763-778(2019)
