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Niraparib tosylate

Cat. No.：1038915-73-9

  • CAS No. ：1038915-73-9

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    • 产品名称: Niraparib tosylate
      CAS No.: 1038915-73-9
      Chemical Name:
      Synonyms:尼拉帕尼对苯甲磺酸盐; MK-4827 tosylate
      分子量:492.59
      分子式:C₂₆H₂₈N₄O₄S
      SMILES:NC(C1=CC=CC2=CN(C3=CC=C([C@H]4CNCCC4)C=C3)N=C21)=O.O=S(C5=CC=C(C)C=C5)(O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 0.98
    • Jones, P., Altmura, S., Boueres, J., et al.Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumorsJ. Med. Chem.52(22),7170-7185(2009)', 'Yuan, Y., Liao, Y.M., Hsueh, C.T., et al.Novel targeted therapeutics: Inhibitors of MDM2, ALK and PARPJ. Hematol. Oncol.4(16),1-14(2011)', 'Wang, L., Mason, K.A., Ang, K.K., et al.MK-4827, a PARP-1/-2 inhibitor, strongly enhances response of human lung and breast cancer xenografts to radiationInvest New Drugs30(6),2113-2120(2012)', 'Mirza, M.R., Monk, B.J., Herrstedt, J., et al.Niraparib maintenance therapy in platinum-sensitive, recurrent ovarian cancerN. Engl. J. Med.375(22),2154-2164(2016)
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