Candesartan Cilexetil

Cat. No.：145040-37-5

CAS No. ：145040-37-5

产品名称:	Candesartan Cilexetil
CAS No.:	145040-37-5
Chemical Name:
Synonyms:	坎地沙坦酯; TCV-116
分子量:	610.66
分子式:	C₃₃H₃₄N₆O₆
SMILES:	O=C(C1=C2C(N=C(OCC)N2CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)=CC=C1)OC(OC(OC6CCCCC6)=O)C
存储:	Please store the product under the recommended conditions in theCertificate of Analysis.
运输:	Room temperature in continental US; may vary elsewhere.

Select Batch:

Purity: 0.98

Shibouta, Y., Inada, Y., Ojima, M., et al.Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116)J. Pharmacol. Exp. Ther.266(1),114-120(1993)", 'Gavras, H.Update on the clinical pharmacology of candesartan cilexetilAm. J. Hypertens.13(1 Pt.2),25S-30S(2000)', "Inada, Y., Wada, T., Shibouta, Y., et al.Antihypertensive effects of a highly potent and long-acting angiotensin II subtype-1 receptor antagonist, (+-)-1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H- benzimidazole-7-carboxylate (TCV-116), in various hypertensive ratsJ. Pharmacol. Exp. Ther.268(3),1540-1547(1993)", 'Inada, Y., Wade, T., Ojima, M., et al.Protective effects of candesartan cilexetil (TCV-116) against stroke, kidney dysfunction and cardiac hypertrophy in stroke-prone spontaneously hypertensive ratsClin. Exp. Hypertens.19(7),1079-1099(1997)', 'Bregonzio, C., Seltzer, A., Armando, I., et al.Angiotensin II AT1 receptor blockade selectively enhances brain AT2 receptor expression, and abolishes the cold-restraint stress-induced increase in tyrosine hydroxylase mRNA in the locus coeruleus of spontaneously hypertensive ratsStress11(6),457-466(2008)