NPS-2143 hydrochloride
Cat. No.：YN320185
CAS No. ：324523-20-8
| 产品名称: | NPS-2143 hydrochloride |
| CAS No.: | 324523-20-8 |
| Chemical Name: | 2-chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-benzonitrile, monohydrochloride |
| Synonyms: | SB-262470A hydrochloride |
| 分子量: | 445.38 |
| 分子式: | C₂₄H₂₆Cl₂N₂O₂ |
| SMILES: | N#CC1=C(OC[C@@H](CNC(C)(C)CC2=CC=C3C=CC=CC3=C2)O)C=CC=C1Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NPS-2143 hydrochloride (SB-262470A hydrochloride)，口服活性溶钙剂，是选择性的钙敏感受体(CaSR)拮抗剂。NPS-2143 hydrochloride (SB-262470A hydrochloride) 通过激活表达人 Ca2+受体的 HEK 293 细胞中的 Ca2+受体而引起的胞浆 Ca2+浓度增加 (IC50=43 nM)。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Nemeth, E.F.The search for calcium receptor antagonists (calcilytics)J. Mol. Endocrinol.29,15-21(2002)
Filopanti, M., Corbetta, S., Barbieri, A.M., et al.Pharmacology of the calcium sensing receptorClin. Cases Miner. Bone Metab.10(3),162-165(2013)
Gowen, M., Stroup, G.B., Dodds, R.A., et al.Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic ratsJ. Clin. Invest.105(11),1595-1604(2000)
Nemeth, E.F., DelMar, E.G., Heaton, W.L., et al.Calcilytic compounds: Potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormoneJPET299(1),323-331(2001)
