Strontium Ranelate
Cat. No.：YN321129
CAS No. ：135459-87-9
| 产品名称: | Strontium Ranelate |
| CAS No.: | 135459-87-9 |
| Chemical Name: | 5-[bis(carboxymethyl)amino]-2-carboxy-4-cyano-3-thiopheneacetic acid, distrontium salt |
| Synonyms: | 雷尼酸锶; Distrontium renelate; S12911 |
| 分子量: | 513.49 |
| 分子式: | C₁₂H₆N₂O₈SSr₂ |
| SMILES: | O=C(O[Sr]OC(C1)=O)C2=C1C(C#N)=C(N3CC(O[Sr]OC(C3)=O)=O)S2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Strontium Ranelate (S12911) 是一种抗骨质疏松药物，其作用是通过减少骨吸收并促进骨形成，从而诱导正骨平衡。Strontium Ranelate 还可以激活非骨骼细胞中的钙敏感受体 (CaSR)，从而导致肌醇 1、4、5-三磷酸生成和丝裂原活化的蛋白激酶信号转导。 |
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Baron, R., and Tsouderos, Y.In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiationEur. J. Pharmacol.450(1),11-17(2002)
Buehler, J., Chappuis, P., Saffar, J.L., et al.Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis)Bone29(2),176-179(2001)
