CaCCinh-A01
Cat. No.：YN360039
CAS No. ：407587-33-1
| 产品名称: | CaCCinh-A01 |
| CAS No.: | 407587-33-1 |
| Chemical Name: | 6-(1,1-dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid |
| Synonyms: | TMEM16 Blocker I |
| 分子量: | 347.43 |
| 分子式: | C₁₈H₂₁NO₄S |
| SMILES: | O=C(C1=C(NC(C2=CC=CO2)=O)SC3=C1CCC(C(C)(C)C)C3)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CaCCinh-A01 是TMEM16A和钙激活氯化物通道 (CaCC) 的抑制剂，IC50值分别为 2.1 和 10 μM。 |
| IC50和靶点: | |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
De La Fuente, R., Namkung, W., Mills, A., et al.Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channelMol. Pharmacol.73(3),758-768(2008)
Boedtkjer, D.M.B., Kim, S., Jensen, A.B., et al.New selective inhibitors of calcium-activated chloride channels - T16Ainh-A01, CaCCinh-A01 and MONNA - what do they inhibit?Br. J. Pharmacol.172(16),4158-4172(2015)
Bill, A., Hall, M.L., Borawski, J., et al.Small molecule-facilitated degradation of ANO1 protein: A new targeting approach for anticancer therapeuticsJ. Biol. Chem.289(16),11029-11041(2014)
Kucherenko, Y.V., Wagner-Britz, L., Bernhardt, I., et al.Effect of chloride channel inhibitors on cytosolic Ca2+ Levels and Ca2+-activated K+ (Gardos) channel activity in human red blood cellsJ. Membr. Biol.246(4),315-326(2013)
