Eact
Cat. No.：YN360133
CAS No. ：461000-66-8
| 产品名称: | Eact |
| CAS No.: | 461000-66-8 |
| Chemical Name: | 3,4,5-trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)-benzamide |
| Synonyms: | |
| 分子量: | 428.50 |
| 分子式: | C₂₂H₂₄N₂O₅S |
| SMILES: | O=C(N(CCOC)C1=NC(C2=CC=CC=C2)=CS1)C3=CC(OC)=C(OC)C(OC)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Eact 是一种选择性强的TMEM16A激活剂，直接激活感觉伤害感受器中的 TRPV1 通道，产生瘙痒、急性伤害感受和热敏反应。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Namkung, W., Yao, Z., Finkbeiner, W.E., et al.Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contractionFASEB J.25(11),4048-4062(2011)
Allawzi, A.M., Vang, A., Clements, R.T., et al.Activation of anoctamin-1 limits pulmonary endothelial cell proliferation via p38-mitogen-activated protein kinase-dependent apoptosisAm. J. Respir. Cell Mol. Biol.58(5),658-667(2018)
Liu, S., Feng, J., Luo, J., et al.Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behavioursBr. J. Pharmacol.173(7),1208-1218(2016)
