Tretazicar
Cat. No.：YN290261
CAS No. ：21919-05-1
| 产品名称: | Tretazicar |
| CAS No.: | 21919-05-1 |
| Chemical Name: | 5-(1-aziridinyl)-2,4-dinitro-benzamide |
| Synonyms: | CB 1954 |
| 分子量: | 252.18 |
| 分子式: | C₉H₈N₄O₅ |
| SMILES: | O=C(N)C1=CC(N2CC2)=C([N+]([O-])=O)C=C1[N+]([O-])=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tretazicar (CB 1954) 是一种抗肿瘤前药，对 Walker 256 大鼠肿瘤细胞系具有很高的效力和选择性。Tretazicar 酶促活化后生成双功能试剂，该试剂可以形成 DNA-DNA 链间交联。大鼠细胞中的 Tretazicar 涉及通过酶 NAD(P)H：醌氧化还原酶1 (NQO1) 将其 4-硝基还原为 4-羟基胺。 |
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Knox, R.J., Jenkins, T.C., Hobbs, S.M., et al.Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapyCancer Res.60(15),4179-4186(2000)
