Cyclophosphamide hydrate
Cat. No.：YN290416
| 产品名称: | Cyclophosphamide hydrate |
| CAS No.: | 6055-19-2 |
| Chemical Name: | N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine, monohydrate |
| Synonyms: | 环磷酰胺水合物; Cyclophosphamide monohydrate |
| 分子量: | 279.10 |
| 分子式: | C₇H₁₇Cl₂N₂O₃P |
| SMILES: | ClCCN(CCCl)P1(OCCCN1)=O.[H]O[H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cyclophosphamide hydrate 是一种合成的DNA Alkylator，在化学上与氮芥类有关，具有抗肿瘤及免疫抑制活性。 |
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de Jonge, M.E., Huitema, A.D.R., Rodenhuis, S., et al.Clinical pharmacokinetics of cyclophosphamideClin. Pharmacokinet.44(11),1135-1164(2005)
DeNeve, W., Valeriote, F., Edelstein, M., et al.In vivo DNA cross-linking by cyclophosphamide: Comparison of human chronic lymphatic leukemia cells with mouse L1210 leukemia and normal bone marrow cellsCancer Res.49(13),3452-3456(1989)
Huyan, X.-H., Lin, Y.-P., Gao, T., et al.Immunosuppressive effect of cyclophosphamide on white blood cells and lymphocyte subpopulations from peripheral blood of Balb/c miceInt. Immunopharmacol.11(9),1293-1297(2011)
Caglayan, C., Temel, Y., Kandemir, F.M., et al.Naringin protects against cyclophosphamide-induced hepatotoxicity and nephrotoxicity through modulation of oxidative stress, inflammation, apoptosis, autophagy, and DNA damageEnviron. Sci. Pollut. Res. Int.25(21),20968-20984(2018)
Gibson, J.E., and Becker, B.A.Teratogenicity of structural truncates of cyclophosphamide in miceTeratology4(2),141-150(1971)
