GNE-781
Cat. No.：YN310098
CAS No. ：1936422-33-1
| 产品名称: | GNE-781 |
| CAS No.: | 1936422-33-1 |
| Chemical Name: | 3-[7-(Difluoromethyl)-3,4-dihydro-6-(1-methyl-1H-pyrazol-4-yl)-1(2H)-quinolinyl]-1,4,6,7-tetrahydro-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-5H-pyrazolo[4,3-c]pyridine-5-carboxamide |
| Synonyms: | |
| 分子量: | 525.59 |
| 分子式: | C₂₇H₃₃F₂N₇O₂ |
| SMILES: | O=C(N1CCC(N(C2CCOCC2)N=C3N4CCCC5=C4C=C(C(F)F)C(C6=CN(C)N=C6)=C5)=C3C1)NC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GNE-781 是一种有效的，具有口服活性的选择性CBP抑制剂，在 TR-FRET 实验中IC50 sub>为 0.94 nM。GNE-781 还抑制BRET和BRD4 (1)，IC50分别为 6.2 nM 和 5100 nM。GNE-781 在 MOLM-16 AML 异种移植模型中显示抗肿瘤活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Romero, F.A.
et al.: J. Med. Chem, DOI: 10.1021/acs.jmedchem.7b00796 (2017)
