BAZ2-ICR
Cat. No.：YN310319
CAS No. ：1665195-94-7
| 产品名称: | BAZ2-ICR |
| CAS No.: | 1665195-94-7 |
| Chemical Name: | 4-[4-(1-methyl-1H-pyrazol-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)ethyl]-1H-imidazol-5-yl]-benzonitrile |
| Synonyms: | BAZ2ICR |
| 分子量: | 357.41 |
| 分子式: | C₂₀H₁₉N₇ |
| SMILES: | N#CC1=CC=C(C2=C(C3=CN(C)N=C3)N=CN2CCC4=CN(C)N=C4)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BAZ2-ICR 是一种有效的，选择性的，具有细胞活性和口服活性的BAZ2A/B溴结构域抑制剂，IC50分别为 130 nM 和 180 nM，Kd分别为 109 nM 和 170 nM。BAZ2-ICR 结合BAZ2A/B的选择性比 CECR2 高 10-15 倍，比其他溴结构域 高 100 倍以上。BAZ2-ICR 是一种表观遗传化学探针。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
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Arking, D.E., Junttila, M.J., Goyette, P., et al.Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individualsPLoS Genet.7(6),1-9(2011)
Drouin, L., McGrath, S., Vidler, L.R., et al.Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2BJ. Med. Chem.58(5),2553-2559(2015)
