MI-463
Cat. No.：YN310331
CAS No. ：1628317-18-9
| 产品名称: | MI-463 |
| CAS No.: | 1628317-18-9 |
| Chemical Name: | 4-methyl-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1H-indole-2-carbonitrile |
| Synonyms: | MI-463;MI463 |
| 分子量: | 484.54 |
| 分子式: | C₂₄H₂₃F₃N₆S |
| SMILES: | FC(F)(F)CC(S1)=CC2=C1N=CN=C2NC3CCN(CC4=CC=C(NC(C#N)=C5)C5=C4C)CC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MI-463是高效，有口服活性的menin-mLL相互作用的小分子抑制剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Borkin, D., Pollock, J., Kempinska, K., et al.Property focused structure-based optimization of small molecule inhibitors of the protein-protein interaction between menin and mixed lineage leukemia (MLL)J. Med. Chem.59(3),892-913(2016)
Borkin, D., He, S., Miao, H., et al.Pharmacologic inhibition of the menin-MLL interaction blocks progression of MLL leukemia in vivoCancer Cell27(4),589-602(2015)
