Alobresib
Cat. No.：YN310101
CAS No. ：1637771-14-2
| 产品名称: | Alobresib |
| CAS No.: | 1637771-14-2 |
| Chemical Name: | 2-cyclopropyl-5-(3,5-dimethyl-4-isoxazolyl)-α,α-di-2-pyridinyl-1H-benzimidazole-7-methanol |
| Synonyms: | GS-5829 |
| 分子量: | 437.49 |
| 分子式: | C₂₆H₂₃N₅O₂ |
| SMILES: | OC(C1=CC=CC=N1)(C2=CC=CC=N2)C3=C(NC(C4CC4)=N5)C5=CC(C(C(C)=NO6)=C6C)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Alobresib (GS-5829) 是一种BET溴结构域抑制剂，Alobresib 可用于复发且耐药的过表达 c-Myc 的子宫浆液性癌的相关研究。 |
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Kim, E., Hacken, E.T., Sivina, M., et al.The BET inhibitor GS-5829 targets chronic lymphocytic leukemia cells and their supportive microenvironmentLeukemia34(6),1588-1598(2020)
Bonazzoli, E., Predolini, F., Cocco, E., et al.Inhibition of BET bromodomain proteins with GS-5829 and GS-626510 in uterine serous carcinoma, a biologically aggressive variant of endometrial cancerClin. Cancer Res.24(19),4845-4853(2018)
