HJB97
Cat. No.：YN310128
CAS No. ：2093391-24-1
| 产品名称: | HJB97 |
| CAS No.: | 2093391-24-1 |
| Chemical Name: | |
| Synonyms: | HJB 97;HJB97 |
| 分子量: | 500.55 |
| 分子式: | C₂₆H₂₈N₈O₃ |
| SMILES: | O=C(C1=NC(NC2=CC(C3CC3)=NN2CC)=C4C(NC5=C4C=C(OC)C(C6=C(C)ON=C6C)=C5)=N1)NC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | HJB97 是一种高亲和力BET抑制剂，Ki值分别为 0.9 nM (BRD2 BD1)，0.27 nM (BRD2 BD2)，0.18 nM (BRD3 BD1)，0.21 nM (BRD3 BD2)，0.5 nM (BRD4 BD1)，1.0 nM (BRD4 BD2)。HJB97 可用于开发设计PROTAC BET的降解剂，具有抗肿瘤活性。 |
| IC50和靶点: | [{name:"BRD4 BD1:0.5±0.2 nM (Ki)"},{name: "BRD4 BD1:7.0±0.6 nM (IC50)"},{name: "BRD4 BD2:1.0±0.1 nM (Ki)"},{name: "BRD4 BD2:7.0±0.1 nM (IC50)"},{name: "BRD2 BD1:0.9±0.2 nM (Ki)"},{name: "BRD2 BD2:0.27±0.09 nM (Ki)"},{name: "BRD2 BD1:3.1±0.7 nM (IC50)"},{name: "BRD2 BD2:3.9±0.5 nM (IC50)"},{name: "BRD3 BD1:0.18±0.01 nM (Ki)"},{name: "BRD3 BD2:0.21±0.03 nM (Ki)"},{name: "BRD3 BD1:6.6±0.2 nM (IC50)"},{name: "BRD3 BD2:1.9±0.4 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
