Ceritinib
Cat. No.：YN440335
CAS No. ：1032900-25-6
| 产品名称: | Ceritinib |
| CAS No.: | 1032900-25-6 |
| Chemical Name: | LDK378; Ceritinib; Zykadia |
| Synonyms: | 色瑞替尼; LDK378 |
| 分子量: | 558.14 |
| 分子式: | C₂₈H₃₆ClN₅O₃S |
| SMILES: | CC(C)OC1=CC(C2CCNCC2)=C(C)C=C1NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ceritinib (LDK378) 是一种选择性，具有口服活性的且具有 ATP 竞争性的ALK酪氨酸激酶抑制剂，IC50为 200 pM。 Ceritinib (LDK378) 还抑制IGF-1R，InsR和STK22D，IC50值分别为 8、7 和 23 nM。Ceritinib (LDK378) 显示出良好抗肿瘤效力。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Marsilje, T. H., et al.: J. Med. Chem., 56, 5675 (2013)
