SAFit2
Cat. No.：YN330055
CAS No. ：1643125-33-0
| 产品名称: | SAFit2 |
| CAS No.: | 1643125-33-0 |
| Chemical Name: | (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]-2-piperidinecarboxylic acid, (1R)-3-(3,4-dimethoxyphenyl)-1-[3-[2-(4-morpholinyl)ethoxy]phenyl]propyl ester |
| Synonyms: | |
| 分子量: | 802.99 |
| 分子式: | C₄₆H₆₂N₂O₁₀ |
| SMILES: | O=C(N1[C@@H](CCCC1)C(O[C@@H](C2=CC(OCCN3CCOCC3)=CC=C2)CCC4=CC(OC)=C(OC)C=C4)=O)[C@@H](C5CCCCC5)C6=CC(OC)=C(OC)C(OC)=C6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SAFit2 是一个高效且高选择性的 FK506 结合蛋白 51 (FKBP51) 抑制剂，其Ki值为 6 nM，并且能增强AKT2-AS160的结合。 |
| IC50和靶点: | |
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Gaali, S., Kirschner, A., Cuboni, S., et al.Selective inhibitors of the FK506-binding protein 51 by induced fitNat. Chem. Biol.11(1),33-37(2015)
Hartmann, J., Wagner, K.V., Gaali, S., et al.Pharmacological inhibition of the psychiatric risk factor FKBP51 has anxiolytic propertiesJ. Neurosci.35(24),9007-9016(2015)
