Rimiducid
Cat. No.：YN330330
CAS No. ：195514-63-7
规格
价格(RMB)
库存
| 产品名称: | Rimiducid |
| CAS No.: | 195514-63-7 |
| Chemical Name: | 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylic acid, (2S,2'S)-2,2'-[1,2-ethanediylbis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1R)-3-(3,4-dimethoxyphenyl)propylidene]]] ester |
| Synonyms: | AP1903 |
| 分子量: | 1411.63 |
| 分子式: | C₇₈H₉₈N₄O₂₀ |
| SMILES: | COC1=CC=C(CC[C@@H](OC([C@@H]2CCCCN2C([C@@H](CC)C3=CC(OC)=C(OC)C(OC)=C3)=O)=O)C4=CC=CC(OCC(NCCNC(COC5=CC([C@@H](CCC6=CC=C(OC)C(OC)=C6)OC([C@@H]7CCCCN7C([C@H](C8=CC(OC)=C(OC)C(OC)=C8)CC)=O)=O)=CC=C5)=O)=O)=C4)C=C1OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rimiducid (AP1903) 是二聚化剂，其通过交联FKBP结构域起作用，启动Fas信号传导，引起凋亡。Rimiducid (AP1903) 使 Caspase 9 自杀开关二聚化，并迅速诱导细胞凋亡 (apoptosis)。 |
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Clackson, T., Yang, W., Rozamus, L.W., et al.Redesigning an FKBP–ligand interface to generate chemical dimerizers with novel specificityProc. Natl. Acad. Sci. USA95(18),10437-10442(1998)
Thomis, D.C., Marktel, S., Bonini, C., et al.A Fas-based suicide switch in human T cells for the treatment of graft-versus-host diseaseBlood97(5),1249-1257(2022)
