Rapamycin
Cat. No.：YN330058
| 产品名称: | Rapamycin |
| CAS No.: | 53123-88-9 |
| Chemical Name: | (7E,15E,17E,19E)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34aS-Hexadecahydro-9R,27-dihydroxy-3S-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10R,21S-dimethoxy-6R,8,12R,14S,20,26R-hexamethyl-23S,27R-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyc |
| Synonyms: | 雷帕霉素; Sirolimus; AY-22989 |
| 分子量: | 914.17 |
| 分子式: | C₅₁H₇₉NO₁₃ |
| SMILES: | O=C([C@@]1(O)[C@@H](CC[C@@H](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@@H](C)C([C@@H]([C@@H](/C(C)=C/[C@H]2C)O)OC)=O)C)OC)O1)C)C(N3CCCC[C@H]3C(O[C@@H](CC2=O)[C@@H](C[C@H]4C[C@H]([C@H](O)CC4)OC)C)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rapamycin (Sirolimus) 是一种有效且特异性的mTOR抑制剂，作用于 HEK293 细胞，抑制mTOR，IC50为 0.1 nM。Rapamycin 与 FKBP12 结合且抑制mTORC1。Rapamycin 还是一种自噬 (autophagy) 激活剂，免疫抑制剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Kim, Y.C., and Guan, K.-L.mTOR: A pharmacological target for autophagy regulationJ. Clin. Invest.125(1),25-32(2015)
Hosoi, H., Dilling, M.B., Shikata, T., et al.Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cellsCancer Res.59(4),886-894(1999)
Kay, J.E., Kromwel, L., Doe, S.E.A., et al.Inhibition of T and B lymphocyte proliferation by rapamycinImmunology72(4),544-549(1991)
