Everolimus
Cat. No.：YN330057
CAS No. ：159351-69-6
| 产品名称: | Everolimus |
| CAS No.: | 159351-69-6 |
| Chemical Name: | 42-O-(2-hydroxyethyl)-rapamycin |
| Synonyms: | 依维莫司; RAD001; SDZ-RAD |
| 分子量: | 958.22 |
| 分子式: | C₅₃H₈₃NO₁₄ |
| SMILES: | O=C([C@@]1(O)[C@@H](CC[C@@H](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@@H](C)C([C@@H]([C@@H](/C(C)=C/[C@H]2C)O)OC)=O)C)OC)O1)C)C(N3CCCC[C@H]3C(O[C@@H](CC2=O)[C@@H](C[C@H]4C[C@H]([C@H](OCCO)CC4)OC)C)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Everolimus (RAD001) 是一种 Rapamycin 的衍生物，也是一种有效的，选择性的和口服活性的mTOR1抑制剂。Everolimus 与FKBP-12结合可产生免疫抑制复合物。Everolimus 抑制肿瘤细胞增殖并诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)。Everolimus 具有有效的免疫抑制和抗癌活性。 |
| IC50和靶点: | [{name:"mTOR:5-6 nM (IC50)"}] |
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| Solvent & Solubility: |
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Lebwohl, D., Anak, Ö., Sahmoud, T., et al.Development of everolimus, a novel oral mTOR inhibitor, across a spectrum of diseasesAnn. N. Y. Acad. Sci.1291,14-32(2013)
Yunokawa, M., Koizumi, F., Kitamura, Y., et al.Efficacy of everolimus, a novel mTOR inhibitor, against basal-like triple-negative breast cancer cellsCancer Sci.103(9),1665-1671(2012)
Gurk-Turner, C., Manitpisitkul, W., and Cooper, M.A comprehensive review of everolimus clinical reports: A new mammalian target of rapamycin inhibitorTransplantation94(7),659-668(2012)
