IQ-1S free acid
Cat. No.：YN350003
CAS No. ：23146-22-7
规格
价格(RMB)
库存
| 产品名称: | IQ-1S free acid |
| CAS No.: | 23146-22-7 |
| Chemical Name: | 11H-indeno[1,2-b]quinoxalin-11-one, oxime |
| Synonyms: | IQ-1S,IQ-1,IQ-1S (free acid) |
| 分子量: | 247.25 |
| 分子式: | C₁₅H₉N₃O |
| SMILES: | O/N=C1C2=C(C3=NC4=CC=CC=C4N=C3\1)C=CC=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | IQ-1S free acid 是一种NF-κB/激活蛋白1 (AP-1) 抑制剂，IC50为 2.3±0.41 μM。IQ-1S free acid 对三种JNK都具有高的结合亲和力 (Kd值)，对JNK3，JNK1和JNK2的Kd值分别为 100 nM，240 nM 和 360 nM。 |
| IC50和靶点: | [{name:"JNK3:100 nM (Kd)"},{name: "JNK1:240 nM (Kd)"},{name: "JNK2:360 nM (Kd)"},{name: "CK1δ:0.38 μM (Kd)"},{name: "PI3Kγ:0.47 μM (Kd)"},{name: "MKNK2:0.92 μM (Kd)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Schepetkin, I.A., Kirpotina, L.N., Khlebnikov, A.I., et al.Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitorsMol. Pharmacol.81(6),832-845(2012)
