Polyphyllin I
Cat. No.：YN350221
CAS No. ：50773-41-6
| 产品名称: | Polyphyllin I |
| CAS No.: | 50773-41-6 |
| Chemical Name: | (3β,25R)-spirost-5-en-3-yl O-α-L-arabinofuranosyl-(1→4)-O-[6-deoxy-α-L-mannopyranosyl-(1→2)]-β-D-glucopyranoside |
| Synonyms: | 重楼皂苷I |
| 分子量: | 855.02 |
| 分子式: | C₄₄H₇₀O₁₆ |
| SMILES: | C[C@H](CC1)CO[C@]21O[C@@]3([H])C[C@@]4([H])[C@@]5([H])[C@]([C@](CC[C@H](O[C@]6([H])O[C@H](CO)[C@@H](O[C@]7([H])O[C@@H](CO)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O[C@@]8([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O8)C9)(C)C9=CC5)([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Polyphyllin I 是一种从Paris polyphylla中提取的生物活性成分，具有很强的抗肿瘤活性。Polyphyllin I 是JNK信号通路的激活剂，也是PDK1/Akt/mTOR信号传导的抑制剂。Polyphyllin I 诱导自噬，G2/M 期阻滞和细胞凋亡。 |
| IC50和靶点: | |
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Lee, M.S., Yuet-Wa, J.C., Kong, S.K., et al.Effects of polyphyllin D, a steroidal saponin in Paris polyphylla, in growth inhibition of human breast cancer cells and in xenograftCancer Biol. Ther.4(11),1248-1254(2005)
Ong, R.C., Lei, J., Lee, R.K., et al.Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cellsCancer Lett.261(2),158-164(2008)
