Bentamapimod
Cat. No.：YN350151
CAS No. ：848344-36-5
| 产品名称: | Bentamapimod |
| CAS No.: | 848344-36-5 |
| Chemical Name: | α-[2-[[4-(4-morpholinylmethyl)phenyl]methoxy]-4-pyrimidinyl]-2-benzothiazoleacetonitrile |
| Synonyms: | AS 602801 |
| 分子量: | 457.55 |
| 分子式: | C₂₅H₂₃N₅O₂S |
| SMILES: | N#CC(C1=NC(OCC2=CC=C(C=C2)CN3CCOCC3)=NC=C1)C4=NC5=CC=CC=C5S4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bentamapimod (AS 602801) 是一种ATP竞争性的JNK抑制剂，作用于JNK1，JNK2和JNK3，IC50分别为 80 nM，90 nM 和 230 nM。 |
| IC50和靶点: | [{name:"JNK1:80 nM (IC50)"},{name: "JNK2:90 nM (IC50)"},{name: "JNK3:230 nM (IC50)"}] |
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Hussein, M., Chair, D.C., Kyama, C.M., et al.c-Jun NH2-terminal kinase inhibitor bentamapimod reduces induced endometriosis in baboons: An assessor-blind placebo-controlled randomized studyFertil. Steril.105(3),518-824(2016)
Palmer, S.S., Altan, M., Denis, D., et al.Bentamapimod (JNK Inhibitor AS602801) induces regression of endometriotic lesions in animal modelsReprod. Sci.23(1),11-23(2016)
Okada, M., Kuramoto, K., Takeda, H., et al.The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivoOncotarget7(19),27021-27032(2016)
