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JTE-013

Cat. No.：383150-41-2

  • CAS No. ：383150-41-2

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    • 产品名称: JTE-013
      CAS No.: 383150-41-2
      Chemical Name:
      Synonyms:1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea;JTE-013;Jte 013;S1P2 Receptor Antagonist, JTE-013;1-(1,3-Dimethyl-4-isopropyl)-1H-pyrazolo[3,4-b]pyridin-6-yl)-4-(3,5-dichloro-4-pyridinyl)-semicarbazide;pyr
      分子量:408.29
      分子式:C₁₇H₁₉Cl₂N₇O
      SMILES:CC(C1=C2C(N(C)N=C2C)=NC(NNC(NC3=CC(Cl)=NC(Cl)=C3)=O)=C1)C
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 0.98
    • Pitman, M., Lewis, A.C., Davies, L.T., et al.The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolismSci. Rep.12(1),454(2022)', 'Osada, M., Yatomi, Y., Ohmori, T., et al.Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonistBiochem. Biophys. Res. Commun.299(3),483-487(2002)', 'Arikawa, K., Takuwa, N., Yamaguchi, H., et al.Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular rac activityJ. Biol. Chem.278(35),32841-32851(2003)', 'Xu, Q., Chen, J., Zhu, Y., et al.JTE-013 alleviates inflammatory injury and endothelial dysfunction induced by sepsis in vivo and in vitroJ. Surg. Res.265,323-332(2021)
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