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AM966

Cat. No.：1228690-19-4

  • CAS No. ：1228690-19-4

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    • 产品名称: AM966
      CAS No.: 1228690-19-4
      Chemical Name:
      Synonyms:4'-[4-[[[(1R)-1-(2-氯苯基)乙氧基]羰基]氨基]-3-甲基-5-异恶唑基]-联苯-4-乙酸
      分子量:490.93
      分子式:C₂₇H₂₃ClN₂O₅
      SMILES:O=C(O)CC1=CC=C(C2=CC=C(C3=C(NC(O[C@@H](C4=CC=CC=C4Cl)C)=O)C(C)=NO3)C=C2)C=C1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 0.98
    • Swaney, J.S., Chapman, C., Correa, L.D., et al.A novel, orally active LPA1 receptor antagonist inhibits lung fibrosis in the mouse bleomycin modelBr. J. Pharmacol.160(7),1699-1713(2010)', 'Olianas, M.C., Dedoni, S., and Onali, P.Antidepressants activate the lysophosphatidic acid receptor LPA1 to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblastsBiochem. Pharmacol.95(4),311-323(2015)', 'Cai, J., Wei, J., Li, S., et al.AM966, an antagonist of lysophosphatidic acid Receptor 1, increases lung microvascular endothelial permeability through activation of Rho signaling pathway and phosphorylation of VE-cadherinMediators Inflamm.2017,6893560(2017)
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