Pifithrin-α, p-Nitro, Cyclic
Cat. No.：YN270165
CAS No. ：60477-38-5
| 产品名称: | Pifithrin-α, p-Nitro, Cyclic |
| CAS No.: | 60477-38-5 |
| Chemical Name: | 5,6,7,8-tetrahydro-2-(4-nitrophenyl)-imidazo[2,1-b]benzothiazole |
| Synonyms: | PFN-α |
| 分子量: | 299.35 |
| 分子式: | C₁₅H₁₃N₃O₂S |
| SMILES: | O=[N+]([O-])C1=CC=C(C2=CN3C(SC4=C3CCCC4)=N2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pifithrin-α, p-Nitro, Cyclic (PFN-α)，是细胞通透性的p53抑制剂。Pifithrin-α, p-Nitro, Cyclic 对暴露于 Etoposide 的皮层神经元的保护作用比 Pifithrin-α 强一个数量级 (ED50=30 nM)。Pifithrin-α, p-Nitro, Cyclic 也作为 p53 转录后活性抑制剂。Pifithrin-α, p-Nitro, Cyclic 不阻止 p53 上的 S15 残基磷酸化。 |
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Komarov, P.G., Komarova, E.A., Kondratov, R.V., et al.A chemical inhibitor of p53 that protects mice from the side effects of cancer therapyScience285(5434),1733-1737(1999)
Walton, M.I., Wilson, S.C., Hardcastle, I.R., et al.An evaluation of the ability of pifithrin-α and -β to inhibit p53 function in two wild-type p53 human tumor cell linesMol. Cancer Ther.4(9),1369-1377(2005)
Pietrancosta, N., Moumen, A., Dono, R., et al.Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: Discovery of a highly potent in vivo inhibitor and its action mechanismJ. Med. Chem.49(12),3645-3652(2006)
